N,Nʹ-Diaryl-o-phenylenediamines are precursors to many N-heterocyclic carbenes and are substructures of many medicinal substances, yet there are few routes to synthesize these compounds. This makes the metal-free method recently published by the Pan group particularly attractive.1 The method described by Pan’s group is simple, uses
A recent Synthesis Corner post reviewed work where cyclohexanones acted as convenient starting materials for the synthesis of aromatic compounds through a DMSO/I2 catalyzed route.
Jiao, et al., have recently reported an attractive method to make substituted catechols from cyclohexanones using the simple, mild, metal-free and inexpensive DMSO/I2 catalytic system (Equation 1).
…DMSO/I2 catalyzed direct C(sp2)-H activation of aryls containing electron-donating substituents, resulting in C-S bond formation and access to aryl sulfides