Life Sciences Corner

Storage and Packaging of Active Pharmaceutical Ingredients and Biopharmaceuticals containing Procipient®(Dimethyl Sulfoxide USP, PhEur)

The choice of an appropriate container when packaging pharmaceutical dosage forms is very important. You must first understand which materials are compatible with your application. Glass containers are the most common form of packaging for pharmaceuticals. These are intended for direct contact with pharmaceutical products. Commonly used glass is either composed of Borosilicate Glass or […]

Procipient as a Skin Penetration Enhancer

Mechanism of Action Overview: DMSO as a Skin Penetration Enhancer The Stratum Corneum (SC) provides a strong barrier to human skin and provides resistance against penetration and permeation of active ingredients and drugs. The “brick and mortar” model of skin dates to 1983. In this model, dead corneocytes act as “bricks” which are embedded in […]

Procipient in Parenteral Formulations

DMSO in parenteral formulations: a review of opportunities and challenges Dimethyl sulfoxide (DMSO) possesses unique properties which have led to its adoption as an excipient in pharmaceutical formulations and medical devices. DMSO is now incorporated into a number of regulated products for healthcare and drug delivery applications, including stabilizing product formulations, sustained-release applications, and for […]

In situ forming implant systems

In situ forming implant systems: Kinetics of implant formation and concomitant burst drug release   An in situ forming implant system for the treatment of periodontal disease with chemotherapeutics was first patented by Dunn et al in 1990s1. The system comprised of a water insoluble biodegradable polymer, such as poly(DL-lactide), poly(DL-lactide-co-glycolide) and poly(DL-lactide-co-ε-caprolactone), which is dissolved in a water miscible […]

Parenteral Formulation design and burst drug release

An In situ forming implant typically consists of a polymer dissolved in a suitable water-miscible organic solvent, wherein a drug substance is dispersed or suspended. Drug-loaded implants are formed upon in vivo injection. Following administration, the organic solvent diffuses out in the aqueous environment of the surrounding tissue, resulting in precipitation of the water-insoluble polymer. […]

DMSO and Lidocaine solution

Lidocaine is a local anesthetic which provides loss of sensory, motor, and autonomic function. It does so by binding to the sodium channel in the skin layer and reversibly blocking the nerve endings without causing any damage. It is usually delivered in mucosal, dermal, topical dosage forms. It may also be injected in proximity to […]

Novels polymers for DMSO-based In situ-forming implant systems

The solvent exchange-based in situ-forming implant system is comprised of a water-insoluble, biodegradable and/or non-biodegradable polymer as the matrix. Systems based on non-biodegradable polymers require an invasive surgical intervention to remove the implant from the site of injection. Hence, biodegradable polymers used in implant formationwhich degrades to form non-toxic by-products, have risen in popularity. The most popular […]

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