Parenteral Formulation design and burst drug release
An In situ forming implant typically consists of a polymer dissolved in a suitable water-miscible organic solvent, wherein a drug substance is dispersed or suspended. Drug-loaded implants are formed upon in vivo injection. Following administration, the organic solvent diffuses out in the aqueous environment of the surrounding tissue, resulting in precipitation of the water-insoluble polymer. […]
Dichlorocyclopropene Activation of DMSO for Swern Type Oxidations
Visible-Light-Mediated Synthesis of γ-Ketoesters in DMSO
γ-Ketoesters are common synthetic building blocks. Therefore, diverse synthetic methods have been developed to prepare these compounds. Recently, the Liu group reported a visible-light-mediated method, using compact fluorescent light (CFL), where the oxidative coupling of readily available vinylarenes and bromocarboxylates, followed by a Kornblum-type oxidation in DMSO, furnishes the desired γ-ketoester (equation in Table 1, […]
In situ forming implant systems
In situ forming implant systems: Kinetics of implant formation and concomitant burst drug release An in situ forming implant system for the treatment of periodontal disease with chemotherapeutics was first patented by Dunn et al in 1990s1. The system comprised of a water insoluble biodegradable polymer, such as poly(DL-lactide), poly(DL-lactide-co-glycolide) and poly(DL-lactide-co-ε-caprolactone), which is […]
DMSO/I2-Mediated Synthesis of 3-Thiomethyl Chromones
Procipient in Parenteral Formulations
DMSO in parenteral formulations: a review of opportunities and challenges Dimethyl sulfoxide (DMSO) possesses unique properties which have led to its adoption as an excipient in pharmaceutical formulations and medical devices. DMSO is now incorporated into a number of regulated products for healthcare and drug delivery applications, including stabilizing product formulations, sustained-release applications, and for […]
Gaylord Chemical reviews the DMSO-I2 system in the March 2020 issue of Specialty Chemicals Magazine
This recent publication highlights the emergence of the ‘DMSO-I2 system’ as a green oxidation method. This new class of chemical reactions is gentle, robust, and ecofriendly relative to the established alternatives. Substituted imidazole and regioselctive sulfenylation reactions are highlighted Click here to access the full article
DMSO/I2 Oxidation to Produce Heteroaromatic Aldehydes
Procipient as a Skin Penetration Enhancer
Mechanism of Action Overview: DMSO as a Skin Penetration Enhancer The Stratum Corneum (SC) provides a strong barrier to human skin and provides resistance against penetration and permeation of active ingredients and drugs. The “brick and mortar” model of skin dates to 1983. In this model, dead corneocytes act as “bricks” which are embedded in […]