DMSO has been widely used in gentle and selective oxidations of alcohols (e.g., Swern, Parikh-Doering, and Pfitzner-Moffatt oxidations).
DMSO/I2 metal-free route to functionalize ketones at the α-position
Instances of synthetic methods using DMSO as a reagent/synthon have grown in recent years.
Work toward the efficient synthesis of quinazolin-4-(3H)-ones
…eco-friendly synthesis of 3-chalcogenyl-indoles using the DMSO/I2 catalytic system
…synthesis of β,γ – unsaturated ketones which uses arylacetylenes and ketone starting materials.
…DMSO/I2 catalyzed direct C(sp2)-H activation of aryls containing electron-donating substituents, resulting in C-S bond formation and access to aryl sulfides
Cheon, et al., have demonstrated a highly environmentally benign route to the synthesis of quinazolinones using readily-available aldehydes and anthranilimide (Equation 1).1 This route proceeds through a metal-free aerobic oxidation in wet DMSO.