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Isocoumarins via Pd-Catalyzed Tandem Cascade ReactionIsocoumarins via Pd-Catalyzed Tandem Cascade Reaction

Isocoumarins via Pd-Catalyzed Tandem Cascade Reaction

AUTHORADMIN
Li, Han, and coworkers of the Dalian Institute of Chemical Physics have reported an isocoumarin synthesis that proceeds through a nucleopalladative-oxidation olefination pathway (1). Li, Han, and coworkers report the oxidative coupling of olefins and t-butyl 2-alkynylbenzoates to produce isocoumarins (1) The isocoumarin products formed
A Simple DMSO-Mediated Alkyl Chloride Preparation.A Simple DMSO-Mediated Alkyl Chloride Preparation.

A Simple DMSO-Mediated Alkyl Chloride Preparation.

AUTHORADMIN

Alkyl halides are a most fundamental functional group and are useful in many reactions.  Typically alkyl chlorides are derived from alkanols, and Dudley Snyder of Pennsylvania State reported an attractive synthesis which uses a ‘DMSO-activated’ TMSCl intermediate (1)

DMSO / K2CO3 Terminal Alkyne SynthesisDMSO / K2CO3 Terminal Alkyne Synthesis

DMSO / K2CO3 Terminal Alkyne Synthesis

AUTHORADMIN
A recent report by Cheng, Jia, and Kuang (1) of Tongji University is a useful – and pleasantly straightforward- addition to the methods available for alkyne synthesis. The Terminal Alkyne Synthesis of Kuang et Al. (1) The alkyne functionality is crucial to modern methods (Sonogashira coupling, ’Click’ chemistry, methathesis reactions) and terminal alkynes
DMSO / Superbase α-vinylation of KetonesDMSO / Superbase α-vinylation of Ketones

DMSO / Superbase α-vinylation of Ketones

AUTHORADMIN
The Trofimov group (A.E. Favorsky Irkutsk Institute) has recently published a general synthesis of β,γ – unsaturated ketones which uses arylacetylenes and ketone starting materials.  This provides the  synthetic chemist yet another option for the nonobvious homoenolate synthon /  d3  reagent. The authors provide a considerable list of existing routes

DMSO / K2CO3 Terminal Alkyne Synthesis.

AUTHORLCATON

A recent report by Cheng, Jia, and Kuang (1) of Tongji University is a useful – and pleasantly straightforward- addition to the methods available for alkyne synthesis. The Terminal Alkyne Synthesis of Kuang et Al. (1) The alkyne functionality is crucial to modern methods (Sonogashira coupling, ’Click’ chemistry, methathesis reactions) and terminal alkynes

IBX / DMSOIBX / DMSO

IBX / DMSO

AUTHORADMIN
The report of Frigerio and Santagostino (1) that 2-iodoxybenzoic acid is an efficient and mild alcohol oxidant in DMSO was initially published in 1994. An analogue of the previously reported 12-I-5 Dess-Martin Periodinane, the IBX / DMSO reagent has some attractive features as an oxidant.

A simple DMSO-mediated alkyl chloride preparation.

AUTHORLCATON

Alkyl halides are a most fundamental functional group and are useful in many reactions.  Typically alkyl chlorides are derived from alkanols, and Dudley Snyder of Pennsylvania State reported an attractive synthesis which uses a ‘DMSO-activated’ TMSCl intermediate (1) An example from the Dudley paper (1) There are some

Isocoumarins via Pd-Catalyzed Tandem Cascade Reaction.

AUTHORLCATON

Li, Han, and coworkers of the Dalian Institute of Chemical Physics have reported an isocoumarin synthesis that proceeds through a nucleopalladative-oxidation olefination pathway (1). Li, Han, and coworkers report the oxidative coupling of olefins and t-butyl 2-alkynylbenzoates to produce isocoumarins (1) The isocoumarin products formed

One Pot Benzimidazole Synthesis.

AUTHORLCATON

A recent report (1) from workers at Chonnam National University (Gwangju, Korea)  describes a benzimidazole synthesis which:  produces good product yields (40-98%, for about 30 examples) and proceeds in one pot from three readily available components: sodium azide, an aldehyde, and 2-haloanilines shows good functional group tolerance(nitro-, ester-, chloro-,

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