An In situ forming implant typically consists of a polymer dissolved in a suitable water-miscible organic solvent, wherein a drug substance is dispersed or suspended. Drug-loaded implants are formed upon in vivo injection. Following administration, the organic solvent diffuses out in the aqueous environment of
In situ forming implant systems: Kinetics of implant formation and concomitant burst drug release An in situ forming implant system for the treatment of periodontal disease with chemotherapeutics was first patented by Dunn et al in 1990s1. The system comprised of a water insoluble
DMSO in parenteral formulations: a review of opportunities and challenges Dimethyl sulfoxide (DMSO) possesses unique properties which have led to its adoption as an excipient in pharmaceutical formulations and medical devices. DMSO is now incorporated into a number of regulated products for healthcare and drug
Mechanism of Action Overview: DMSO as a Skin Penetration Enhancer The Stratum Corneum (SC) provides a strong barrier to human skin and provides resistance against penetration and permeation of active ingredients and drugs. The “brick and mortar” model of skin dates to 1983. In this
The choice of an appropriate container when packaging pharmaceutical dosage forms is very important. You must first understand which materials are compatible with your application. Glass containers are the most common form of packaging for pharmaceuticals.