Replace A Problem Solvent

Thoughtful solvent selection enables companies to reduce the environmental impact of their products and processes, support safer workplace settings, and provide their customers a safer user experience. The first steps required in selecting a suitable alternative for a problematic solvent involves information gathering. The information found in Gaylord’s Solvent Replacement site is intended to provide starting information to those interested in finding a safer solvent for their products and processes. In addition to this information, Gaylord offers consultation to assist companies seeking to work with DMSO.

Please contact us for any formulation support needs, we’re happy to help.

Powerful and Safe
Solvent ClassSolventCAS#mp,°Cbp,°CWater Solubility
g/100g H20 @ 25°C
Evaporation Rate
(BuOAc=1)
VOCFlammability
Flash Point,
°C (CC)
Legislative Restrictions
Alcoholn-butanol 71-36-3-89.811790.46100%29
Isopropyl Alcohol (IPA) 67-63-0-89.582.3Miscible1.7100%12
Ethanol 64-17-5-114.178.2Miscible1.7100%13
Methanol 67-56-1-9864.7Miscible2.9100%11
Aliphatic HydrocarbonMineral Spirits8052-41-3-58149-213Insoluble0.13100%40
Hexane110-54-3-9569Insoluble8.3100%
Aromatic Hydrocarbon AR-150 64742-94-5N/A179Negligible 0.07100%66
Toluene 108-88-3-951110.072.24100%4
Benzene71-43-25.580.11.883.5100%-11.63
Carboxylic Acid Formic Acid 64-18-68.3101Miscible2.1100%50
Acetic Acid 64-19-716.7118Miscible0.97100%40
Dipolar AproticDimethyl Sulfoxide 67-68-418.55189Miscible0.026100%89
N, N - Dimethyl Acetamide (DMAC)129-19-5-20165Miscible0.2100%63
N-Methyl pyrrolidone (NMP) 9872-50-4-242021000.03806-1026 g/L86REACH banned1
Acetonitrile (ACN) 75-05-8-4681Miscible5.8100%6
N, N - Dimethyl Formamide (DMF)68-12-2-61153Miscible0.17100%58
Nitromethane75-52-5-28.7101.21111.3100%36
EsterPropylene Carbonate108-32-7-49241250.005Exempt132
Ethyl Acetate (ETAC) 141-78-6-8477104.1100%-3
Methyl Soyate 67784-80-9>200Insoluble<14%>94
EtherTetrahydrofuran (THF) 109-99-9-10866Miscible8100%-17
1,3 Dioxolane 646-06-0-9575Miscible3.5100%-3
1,4-Dioxane12-91-111.8101Miscible2.7100%12
Diethyl Ether60-29-7-11634.6811.8100%-40
Butyl Cellusolve (Carbitol) 111-90-0-76202Miscible0.0191
Halogenated HydrocarbonDichloromethane 75-09-2-9740227.5Exempt
Parachlorobenzotrifluoride (PCBTF) 98-56-6-36138Insoluble0.9Exempt43
Chloroform67-66-3-63.561.27.9511.6100%
KetoneAcetone 67-64-1-9556Miscible6.3Exempt-17
Methyl Isobutyl Ketone (MIBK)108-10-1-8411721.6100%14
Water 7732-18-50100-0.3None