DMSO is known to be a valuable source of a variety of one carbon synthons.1 New work by Tiwari et al. uses DMSO as the one carbon source in an atom-economical and environmentally benign approach to the synthesis of 3-substituted quinolones.2
Organosulfur compounds are common in the pharmaceutical industry. Recent reports estimate that in 2012 about 20% of all pharmaceuticals were organosulfur compounds.1 Therefore, many methods have been developed to incorporate sulfur into organic compounds.
Recently, Tiwari’s group reported a transition-metal-free construction of 3-ketoquinolines from readily-available acetophenones and anthranils (Equation 1).1 This method employs DMSO as a solvent and a one carbon source to complete the quinoline carbon skeleton.
Visible light promoted reactions using photosensitizers are rapidly being developed.1 These reactions use visible light as a renewable energy source and a photosensitizer, often eliminating the need for harsh reaction conditions. DMSO is often the solvent of choice for these types of reactions.2
Phenols are widely used in synthetic schemes, and they occur in many natural products and medicinally-useful compounds. Nevertheless, there are only a limited number of methods available to produce the phenolic group from readily available haloarenes.
The list of useful, high-yielding, environmentally-friendly, and inexpensive reactions catalyzed by DMSO/I2 continues to grow (for previous examples, see Synthesis Post articles from March 2017 and June, July, and October 2016).
The development of methods to functionalize imidazo[1,2-α]pyridines is an area of interest due to the frequency of this structural unit in pharmaceutical compounds and functional materials.
Ravikumar and coworkers have developed a new chemoselective oxidation method using DMSO as the oxidant