Synthesis Corner

Dichlorocyclopropene Activation of DMSO for Swern Type Oxidations

  Oxidations of primary alcohols using activated DMSO to produce aldehydes are important reactions. Oxalyl chloride is a common activator for DMSO (Swern oxidation) and has been widely used. However, oxalyl chloride has some drawbacks in that it is volatile and toxic. Additionally, the oxalyl chloride/DMSO pair must be kept cold (less than –60 °C) […]

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