A recent report (1) from workers at Chonnam National University (Gwangju, Korea) describes a benzimidazole synthesis which: produces good product yields (40-98%, for about 30 examples) and proceeds in one pot from three readily available components: sodium azide, an aldehyde, and 2-haloanilines shows good functional group tolerance(nitro-, ester-, chloro-, and various heterocyclic functionalities on the aldehyde or haloaniline component). […]
The work of Lee, Song and coworkers (1) provides an versatile route to symmetrical and unsymmetrical diarylalkynes. Their method is complementary to the powerful Sonagashira coupling of aryl halides and alkynes, and offers an alternative to the established ways to make diarylalkynes.
Our second set of evaluations was guided by the work of Bahrami, Khodaei, and coworkers (1). Their sulfide oxidation method seemed attractive for our purposes, and there were several examples given which were structurally similar to our target compounds. The oxidation procedure of Bahrami, Khodaei and coworkers (1) Some features of this method: fast reaction […]
The sulfide oxidation procedure of Page and coworkers (1) Our first trial was based on the work of Page and coworkers at the University of Liverpool (1). A first look at this procedure suggested it would be simple to implement in the lab and could be used to produce preparative quantities of the sulfoxide we required. Features […]
The lab recently required some small (5-10g) samples of some simple dialkyl sulfoxides. This led us to investigate dialkylsulfide oxidation procedures capable of producing these compounds selectively, with minimal overoxidation to sulfone byproducts. There are, of course, many ways to go about this reaction. Hydrogen peroxide in the presence of a Lewis acid (1), Caro’s […]