Cheon, et al., have demonstrated a highly environmentally benign route to the synthesis of quinazolinones using readily-available aldehydes and anthranilimide (Equation 1).1 This route proceeds through a metal-free aerobic oxidation in wet DMSO.
Punniyamurthy, et al., have recently reported a copper-catalyzed one pot route to substituted benzimidazoles using DMSO as the solvent (Equation 1).1 *Exceptions: when R2 = 4-Me and R1= 4-CF3, 49%; 4,5-dimethyl 10%; 4-NO2, 0%. One example of aliphatic aldehyde also gives a good yield. The
The Trofimov group (A.E. Favorsky Irkutsk Institute) has recently published a general synthesis of β,γ – unsaturated ketones which uses arylacetylenes and ketone starting materials. This provides the synthetic chemist yet another option for the nonobvious homoenolate synthon / d3 reagent. The authors provide a considerable list of existing routes