DMSO (Dimethyl Sulfoxide)

Dimethyl Sulfoxide (DMSO) is a highly polar and water miscible organic liquid. It is essentially odorless, and has a low level of toxicity. As do all dipolar aprotic solvents, DMSO has a relatively high boiling point. Gaylord Chemical Company is the world’s leading provider of Dimethyl Sulfoxide (DMSO) products.

DMSO Product Grades

DMSO ACS Reagent Grade is Dimethyl Sulfoxide that conforms to the American Chemical Society’s (ACS) 9th Edition Specifications for Reagent Chemicals. It meets requirements for general solvent use, and is adequate for many basic applications.

Key Applications

Analytical Applications wherein UV absorption is not critical. DMSO ACS Reagent Grade may be used as a solvent for non-spectrophotometric methods of analysis. DMSO is miscible with water in all proportions, and is a useful solvent for gas chromatography.

DMSO ACS Spectrophotometric Grade is Dimethyl Sulfoxide that conforms to the American Chemical Society’s (ACS) 9th Edition Specifications for Reagent Chemicals.

In addition to the normal parameters related to purity, this monograph specifies maximum UV absorbance levels at five wavelengths. This grade is the preferred solvent for any form of UV spectrophotometric analysis, due to its guaranteed analytical clarity.

Key Applications

HPLC Mobile Phase Component. The low UV limits of DMSO ACS Spectrophotometric Grade result in minimal interference when using UV detectors in HPLC. The polarity of DMSO can be used to modify the solvent strength of HPLC eluent in reverse phase mode.

General Purpose Analysis Solvent. The nearly universal solvent properties of DMSO allow it to effectively dissolve difficult materials, including many polymers and inorganic materials. DMSO ACS Spectrophotometric Grade is suitable for general UV and visible spectrophotometry, IR spectroscopy, and all methods that demand solvent purity and low levels of UV absorbance.

Solvent for High Throughput Screening of Investigational Compounds. The analytical clarity of this product, along with the ability to readily dissolve a wide range of compounds, make this grade ideal for HTS applications.

DMSO Anhydrous Grade has an extremely low moisture content produced under exacting manufacturing conditions to ensure dryness.

In certain analytical methods, water offers unwanted interference and can provide spurious information. This is especially true in IR Spectroscopy, wherein a small amount of water can obscure a large portion of the spectrum. In synthesis, DMSO Anhydrous Grade contains less than 50 ppm water, and minimizes losses to side reactions.

Key Applications

Compound Library Management. DMSO Anhydrous Grade may be used to store materials for later testing. The low water levels minimize degradation that may occur through association with water and hydrolysis. Compounds also stay in solution better in dry DMSO.

Water-Sensitive Compound Synthesis. Water present in DMSO can react with strong bases such as sodium hydride, butyllithium, and alkoxides. This can result in lower yields, and byproduct formation.

Water-Sensitive Analytical Applications. The potent solvent strength of DMSO makes it a valuable medium for the analysis and characterization of difficult-to-dissolve compounds and polymers.

DMSO EL 10 Grade has extremely low metals content and is an essential component in photoresist stripping products during the manufacture of semiconductor devices and TFT-LCD displays.

Key Applications

Thin Film Transistor – Liquid Crystal Display (TFT – LCD) production: as a photoresist stripping reagent during the photolithographic process.

Manufacture of Semiconductors: as a photoresist stripper, and post-etch rinsing solvent.

As a safer alternative to the use of NMP in electronics applications.

DMSO Enviro-S® Grade is an environmentally-friendly alternative to the use of other sulfur chemical in catalyst presulfiding and ethylene furnace passivation. It offers a unique combination of low toxicity, low odor, and high sulfur content for use in the petrochemical industry. DMSO Enviro-S® Grade is important in the presulfiding of hydrodenitrification (HDN) and hydrodesulfurization (HDS) catalysts.

Key Applications

When low odor is an important operational concern, DMSO Enviro-S® Grade offers a proven sulfur source without the unpleasant odor of alternative process chemicals.

DMSO Industrial Grade is a technical grade suitable for use in common industrial and “green” solvent cleaning applications, polymer synthesis and processing.

Key Applications

Solvent cleaning applications requiring high solubility performance.

Processing solvent in operations such as casting polymeric membranes and synthetic fiber production.

Reaction solvent in active ingredient synthesis and blending in agrichemical formulations.

Procipient®(Dimethyl Sulfoxide USP, Ph. Eur.) is the only grade of DMSO suitable for Healthcare and Drug Delivery applications. Gaylord Chemical’s USP grade is the only DMSO that is manufactured under cGMP conditions, in compliance with API guidelines. Supported by a Drug Master File (DMF) on file with the FDA and Health Canada, the product conforms to both the USP and Ph. Eur. Monographs.

Procipient® is the grade of DMSO required in finished pharmaceutical dosage forms. The FDA CDER Inactive Ingredient Database lists applications for this grade. When the highest purity is required, Gaylord is your best resource.

Pharmaceutical Technology publishes a detailed review of FDA regulated applications which incorporate Dimethyl Sulfoxide USP. This paper provides a precedence of use overview for DMSO excipient and active ingredient applications.

Key Applications

Excipient in Drug Delivery Applications to enhance the efficacy of therapeutic agents through controlled release.

Non-toxic solvent of polymers in Medical Devices.

Cryopreservation of biological cells in cell culture and drug delivery as well as storage of human umbilical cord blood, hematopoietic stem cells, and biological tissue.

Active Pharmaceutical Ingredient for intravesicular instillation in the treatment of interstitial cystitis.

DMSO Synthesis Grade is produced to an exacting quality standard specifically for the synthesis of Active Pharmaceutical Ingredients (API). DMSO Synthesis Grade simplifies the manufacturing process by contributing minimal process impurities while providing a predictably low moisture level.

It is the appropriate choice in any chemical synthesis where the final purity of the finished compound is critical.

Key Applications

Preferred solvent and/or reagent choice in many mild and selective oxidations such as the Swern and Kornblum reactions.

Active pharmaceutical ingredient manufacturing where highly pure reaction solvents are required.

Related Resources