What are DMSO and DMS?


Dimethyl Sulfoxide (DMSO) is a highly polar and water miscible organic liquid. It is essentially odorless, and has a low level of toxicity. As do all dipolar aprotic solvents, DMSO has a relatively high boiling point. Gaylord Chemical Company LLC (GCC) is the world’s leading provider of Dimethyl Sulfoxide (DMSO) products.

Since the early 1960’s, the focus of GCC has been on the development of new uses for DMSO. In order to meet customer-specific needs, GCC has pioneered the development of multiple grades of DMSO, including the only DMSO grade that meets USP specifications. The electronics industry values the low-metals grades we produce. Learn more about the grades through the links below.

Molecular formula C2H6OS
Molecular weight 78.13 g/mol
CAS No. [67-68-5]
Appearance Colorless liquid
Specific Gravity 1.1 (20°C)
Melting point 18 °C (66°F)
Boiling point 189 °C (372°F)
Solubility in water Miscible
Acidity (pKa) 35
Flash Point 95°C (open cup)
Viscosity 2.0 cP (25°C)

Key Applications for Dimethyl Sulfoxide

A Superior reaction solvent for the production of Active Pharmaceutical Ingredients and intermediates. Many specific reactions run best in DMSO, producing higher product yields. The high polarity of DMSO allows it to dissolve many compounds that other solvents cannot. DMSO is itself a reactant in a class of environmentally-friendly oxidation reactions.

A component of microelectronic cleaning formulations. Special DMSO products containing trace metals levels are important in surface cleaning operations involved with microelectronic device production. DMSO is used in lithographic cleaning steps as a photoresist stripper and in Cu post-etch residue removal (PERR) products.

As a cryopreservation agent. DMSO has the unusual ability to depress the freezing point of water dramatically, while maintaining viability with many cell and tissue types. This has led to its use in cryopreservation media for stem cells derived from human umbilical cord blood and reproductive tissue.

As a production and processing solvent for polymers. DMSO is used to produce carbon fiber and certain high-performance polymers. As is can dissolve many polymers it  can be used to cast polymeric films and fibers useful to the manufacture of purification membranes. DMSO can be used to clean polymeric residue(polyurethane/polyester) from parts manufacturing.


Dimethyl Sulfide (DMS) is a low molecular weight sulfur compound with a distinctive garlic-like odor. It possesses a low level of toxicity, and is used as a flavor component in the US and other parts of the world.

DMS Exact-S™ Grade has applications in the hydrocarbon industry, including the production of ethylene. Dimethyl Sulfide is also used in certain chemical reactions of importance to the pharmaceutical Industry.

Molecular formula C2H6S
Molecular weight
78.13 g/mol
Appearance Colorless liquid
Boiling point 37 °C
Melting point -98.3°C (-145°F)
Solubility in water Max 2% w/v (25°C)
Flashpoint -48 deg C (-54 deg F)

Key Applications for Dimethyl Sulfide

As an effective presulfiding agent. DMS is used as a sulfur source for industrial catalysts used in hydrodesulfurization, hydrodenitrification, and catalytic cracking. These catalysts are supplied in their oxide form, and must be modified with sulfur prior to use

As a furnace passivation agent. The service lifetime of pyrolysis furnace tubes used to manufacture ethylene is extended when treated with low levels of DMS. Furnace tubes used to reduce iron ore are protected in a similar way.

As a “back-up” odorant in gas products. DMS is blended with common gas odorants as a protective measure. When odorants such as methyl mercaptan oxidize, their odor diminishes. DMS is not as susceptible to this problem.

In chemical synthesis, DMS is alkylated to produce trimethylsulfonium halides, which are useful epoxidation reagents. DMS-BH3 is used in hydroboration-oxidation and related reactions.