MATERIAL
SAFETY
DATA
SHEET
September
12,
2007
DIMETHYL
SULFOXIDE
(DMSO)
MSDS
GCC1-9
4
Stability:
Stable
Conditions
to avoid:
Prolonged
heating above 150
o
C (302
o
F) can
cause rapid,
exothermic
decomposition
Materials
to avoid:
Organic
and inorganic acid chlorides, strong oxidizing agents,
alkali
metals, hydrobromic acid, acidic solutions of alkali bromides
Hazardous
decomposition products: Sulfur dioxide, formaldehyde, methyl mercaptan,
dimethyl
sulfide,
dimethyl disulfide, and bis (methylthio) methane
Hazardous
polymerization:
Will
not occur. No stabilizers are needed or present.
Data
for Dimethyl Sulfoxide:
Acute
Toxicity Data:
Oral
LD-50 (male rat):
14,500-28,300
mg/kg
Inhalation
(rat):
No mortality
rate @ 2,900 mg/m
3
(900
ppm)/ 24 hrs.
Dermal
LD-50 (rat):
40,000
mg/kg
Skin
irritation (human):
Mild
Repeated
skin application (human): Slight irritation
Skin sensitization (human):
None
by EC protocols
Eye
irritation (human):
None
by EC protocols
Subchronic
Toxicity Data:
**
Oral
study (13 weeks, rat): LOEL = 8800 mg/kg/day (minor target organ effects:
liver)
(reduced body weight gain): NOEL = 1100 mg/kg/day
Inhalation study (13 weeks, rat): NOAEL = 0.964 mg/L (302 ppm)
**
Note - definitions for data:
LOEL
= lowest observed effect level
NOAEL
= no observed adverse effect level NOEL = no observed effect level.
Developmental
Toxicity Data:
DMSO
is not considered to be directly embryotoxic and has been shown to be a successful
cryoprotectant for mammalian semen and embryos.
A mouse teratology NOEL of 12 g/kg/day has been established based
on research with a 50%
DMSO solution administered orally. Teratology data suggests that:
1. DMSO is not a teratogen to mammals when administered via oral and dermal
routes at dose
level that do not produce overt maternal toxicity.
2. DMSO is not a teratogen at low dose levels regardless of the route of administration.
3. The teratogenic potential of DMSO is dependent on route of administration,
the dose level
and the gestational time of exposure, but in all cases is extremely low or
non-existent.
Mutagenicity/Genotoxicity
Data:
Salmonella
typhimurium assay (Ames test): negative (+/- activation). DMSO is used as
a
neutral solvent in the Ames mutagen test.
Introduction:
This
environmental effects summary is written to assist in addressing emergencies
created by
an accidental spill which might occur during shipment or handling of this
material. It is not
meant to address discharges to sanitary sewers or publicly owned treatment
works.
Aquatic
Toxicity:
The
LC
50
(96
hrs.) for ten species of fish range from 32,500 to 43,000 ppm. The LC
50
for
two
species
of protozoans are 32,000 and 38,000 ppm. The concentration required to inhibit
growth (EC
50
) for
five species of blue-green algae and one green algae species ranged
from 0.4 to
4.0%.
DMSO is non-bio-accumulating since the log of the octanol/water partition
coefficient is
2.03.
10.
STABILITY AND REACTIVITY
11.
TOXICOLOGICAL INFORMATION
12.
ECOLOGICAL INFORMATION