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11
REFERENCES
The data cited are from published papers in the medical and scientific literature. The evaluation of exposure
and protection is from Crown Zellerbach and Gaylord Chemical's experience during almost 40 years of manufac-
turing and handling DMSO.

1. Smith, E.R.; Hadidian, Z. and Mason, M.M. "The Single- and Repeated-Dose Toxicity of Dimethyl Sulfox-
ide," Ann. New York Acad. Sci., 141, 96 (1967).

Tox A. David, N. A. "The Pharmacology of Dimethyl Sulfoxide," Ann. Rev. of Pharmac. 12, 353-374
(1972).
Tox B. Jacob, S. W. and Wood, D.C. "Dimethyl Sulfoxide (DMSO) - Toxicology, Pharmacology and
Chemical Experience," American Journal of Surgery, 114, 414-26 (1967).

Tox C. Jacob, S. W. and Wood, D.C. "Dimethyl Sulfoxide (DMSO) - A Status Report," Clinical Medicine,
78, 21-34 (1971).

Tox D. Mason, M.M. "Toxicology of DMSO in Animals," Basic Concepts of DMSO, Vol. 1, Chpt. 3, 113-
131, Marcel Dekker, New York (1971).

Tox E. Willson, J.E.; Braun, D.E. and Timmins, E.K. "A Toxicologic Study of Dimethyl Sulfoxide," Toxicol-
ogy and Applied Pharmacology, 7 104-112 (1965).

2. Brobyn, R. D. "The Human Toxicology of Dimethyl Sulfoxide," Ann. New York Acad. Sci., 243, 497
(1975).

3. Rubin, L.F. and K.C. Barnett. "Ocular Effects of Oral and Dermal Application of Dimethyl Sulfoxide in
Animals,". Ann. N.Y. Acad. Sci. 141: 333-345, (1967).
Smith, E.R., M.M. Mason and E. Epstein. "The Ocular Effects of Repeated Dermal Applications of Di-
methyl Sulfoxide to Dogs and Monkeys," J. Pharmacol. Exp. Ther., 170 (2): 364-370, (1969).

4. Rengstorff, R.H., J.P. Petrali and V.M. Sim. "Cataracts Induced in Guinea Pigs by Acetone, Cyclohexanone
and Dimethyl Sulfoxide," American Journal Optometry, 49: 308-319, (1972).
5. de la Torre, J.C., J.W. Sugeon, T. Ernest and R. Wollman, "Subacute Toxicity of Intravenous Dimethyl
Sulfoxide in Rhesus Monkeys," Journal of Toxicology and Environmental Health, 7: 49-57, (1981).
6. Shirley, H.H., M.K. Lundergan, H.J. Williams and S.L. Spruance. "Lack of Ocular Changes with Dimethyl
Sulfoxide Therapy of Scleroderma," Pharmacotherapy. 9(3): 165-168, (1988).
7. Hull, F.W., D.C. Wood and R.D. Brobyn. "Eye Effects of DMSO: Report of Negative Results." Northwest
Medicine. January 1969: 39-41, (1969).
8. Physicians' Desk Reference (PDR). 48
th
Edition. Medical Economics Data Production Company, Mont-
vale, NJ. pp. 1842-1843, (1994).
9. Pearson, T.W.; Dawson, H.J. and Lackey, H.B. "Natural Occurring Levels of Dimethyl Sulfoxide in Selected
Fruits, Vegetables, Grains, and Beverages," J. Agric. Food Chem., 29, 1089-1091 (1981).