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The
Comparative Reaction Solvent Research
at Gaylord Chemical Company,
L.L.C. systematically compares DMSO performance versus other common solvents
in commercially important reactions. Using established references from the chemi-
cal literature, our scientists test reaction systems to ascertain the yield, selectivity,
and reaction rates of DMSO versus other solvents.
Esterification
is an important organic transformation which converts carboxylic ac-
ids (or their derivatives) into esters, via reaction with an appropriate alcohol. In some
cases the alcohol itself may be employed as a reaction solvent, but many complex
molecules require alcohols for which this approach is impractical. The alcohol may
be too valuable to use in this manner, or may be a solid under the reaction condi-
tions. When this is the case, DMSO is an excellent solvent choice. It often produces
higher reaction yields with improved kinetics
, relative to the other dipolar aprotic sol-
vents.
Gaylord Chemical Company, L.L.C.'s
Comparative Reaction Solvent Research
Examines Esterification
Gaylord Chemical Com-
pany, L.L.C. (GCC) is the
world's leading provider
of Dimethyl Sulfoxide
(DMSO) solutions. Be-
ginning in the early
1960's ,GCC has been
dedicated to the develop-
ment of new uses for
DMSO. In order to meet
customer-specific needs,
GCC has pioneered the
development of multiple
grades of DMSO, includ-
ing DMSO USP.

Gaylord Chemical's solu-
tions-based approach has
contributed to the devel-
opment and growth of
industries including phar-
maceuticals, hydro-
carbons, electronics,
polymers, coatings, agri-
cultural chemicals, and
industrial cleaners.

Gaylord Chemical's head-
quarters are located in
Slidell, Louisiana with
manufacturing, research,
and development facilities
in nearby Bogalusa, Lou-
isiana. GCC remains the
only producer of DMSO in
the Western Hemisphere
.
D M S O
DMSO PRODUCT INFORMATION BULLETIN
dimethyl sulfoxide
and esterification reactions
K
2
CO
3
O
2
N
Cl
C
O
HO
O
2
N
C
O
O
50
o
C
0
10
20
30
40
50
60
70
80
90
100
0
50
100
150
time (min)
y
i
e
l
d

(
%
)
DMSO
NMP
DMF
THF
MeOH
DMSO is particularly useful when working with substrates or alcohols that have
poor
solubility
in less polar solvents.
Bulletin 154B
Oct 2007
Gaylord Chemical Company, L.L.C.
Your Global Leader For DMSO Solutions!
P.O. Box 1209
Slidell, LA 70459-1209 USA
1.800.426.6620 Office
1.985.649.0068 Fax
info@gaylordchemical.com