The
Comparative
Reaction Solvent Research
at Gaylord
Chemical Company,
L.L.C.
systematically compares DMSO performance versus other common solvents
in commercially important reactions. Using established references from the
chemi-
cal literature, our scientists test reaction systems to ascertain the yield,
selectivity,
and reaction rates of DMSO versus other solvents.
Esterification
is an important organic transformation which converts carboxylic ac-
ids
(or their derivatives) into esters, via reaction with an appropriate alcohol.
In some
cases the alcohol itself may be employed as a reaction solvent, but many complex
molecules require alcohols for which this approach is impractical. The alcohol
may
be too valuable to use in this manner, or may be a solid under the reaction
condi-
tions. When this is the case, DMSO is an excellent solvent choice. It often
produces
higher
reaction yields with improved kinetics
, relative
to the other dipolar aprotic sol-
vents.
Gaylord
Chemical Company, L.L.C.'s
Comparative
Reaction Solvent Research
Examines
Esterification
Gaylord
Chemical Com-
pany, L.L.C. (GCC) is the
world's leading provider
of Dimethyl Sulfoxide
(DMSO) solutions. Be-
ginning in the early
1960's ,GCC has been
dedicated to the develop-
ment of new uses for
DMSO. In order to meet
customer-specific needs,
GCC has pioneered the
development of multiple
grades of DMSO, includ-
ing DMSO USP.
Gaylord Chemical's solu-
tions-based approach has
contributed to the devel-
opment and growth of
industries including phar-
maceuticals, hydro-
carbons, electronics,
polymers, coatings, agri-
cultural chemicals, and
industrial cleaners.
Gaylord Chemical's head-
quarters are located in
Slidell, Louisiana with
manufacturing, research,
and development facilities
in nearby Bogalusa, Lou-
isiana. GCC remains the
only producer of DMSO in
the Western Hemisphere
.
D
M S O
DMSO
PRODUCT INFORMATION BULLETIN
dimethyl
sulfoxide
and esterification reactions
K
2
CO
3
O
2
N
Cl
C
O
HO
O
2
N
C
O
O
50
o
C
0
10
20
30
40
50
60
70
80
90
100
0
50
100
150
time
(min)
y
i
e
l
d
(
%
)
DMSO
NMP
DMF
THF
MeOH
DMSO
is particularly useful when working with substrates or alcohols that have
poor
solubility
in less polar solvents.
Bulletin
154B
Oct
2007
Gaylord
Chemical Company, L.L.C.
Your
Global Leader For DMSO Solutions!
P.O.
Box 1209
Slidell,
LA 70459-1209 USA
1.800.426.6620
Office
1.985.649.0068
Fax
info@gaylordchemical.com