Gaylord
Chemical's
Comparative
Reaction Solvent Research
investigates
the Halex Reaction
The
Comparative
Reaction Solvent Research
at Gaylord
Chemical Company,
L.L.C.
systematically compares DMSO performance versus other common sol-
vents in commercially important reactions. Using established references from
the
chemical literature, our scientists test reaction systems to ascertain the
yield, selec-
tivity, and reaction rates of DMSO versus other solvents.
The
Halex
reaction
is one
such reaction. This is the nucleophilic aromatic substitu-
tion
of one halogen atom for another. Halex chemistry is one of the preferred meth-
ods for the synthesis of aromatic fluorides:
We have
investigated the yields obtained using DMSO for a array of industrially per-
tinent aromatic halides, to produce fluoroaromatics. Below is an example wherein
DMSO use provides the highest yields:
Cl
F
NO
2
NO
2
Cl
NO
2
NO
2
F
NO
2
NO
2
F
-
Cl
-
Yield
of 4-Fluoronitrobenzene: Halex reaction
0
10
20
30
40
50
60
70
80
90
DMSO
Sulfolane
DMF
Solvent
tested
%
y
i
e
l
d
prod
uc
t
80
35.7
17
NO
2
Cl
NO
2
F
KF
solvent
Gaylord
Chemical Company,
L.L.C. (GCC) is the world's
leading provider of Dimethyl
Sulfoxide (DMSO) solutions.
Beginning in the early
1960's ,GCC has been dedi-
cated to the development of
new uses for DMSO. In or-
der to meet customer-specific
needs, GCC has pioneered
the development of multiple
grades of DMSO, including
DMSO USP.
Gaylord Chemical's solutions
-based approach has contrib-
uted to the development and
growth of industries including
pharmaceuticals, hydro-
carbons, electronics, poly-
mers, coatings, agricultural
chemicals, and industrial
cleaners.
Gaylord Chemical's head-
quarters are located in Slidell,
Louisiana with manufactur-
ing, research, and develop-
ment facilities in nearby
Bogalusa, Louisiana. GCC
remains the only producer of
DMSO in the Western Hemi-
sphere.
DMSO
PRODUCT INFORMATION BULLETIN
dimethyl
sulfoxide
and the Halex Reaction
D
M S O
Bulletin
151B
Oct
2007
Gaylord
Chemical Company, L.L.C.
Your
Global Leader For DMSO Solutions!
P.O.
Box 1209
Slidell,
LA 70459-1209 USA
1.800.426.6620
Office
1.985.649.0068
Fax
info@gaylordchemical.com