DMSO ACS Reagent Grade is Dimethyl Sulfoxide that conforms to the American Chemical Society’s (ACS) 9th Edition Specifications for Reagent Chemicals.
DMSO is a useful reagent for selective oxidation of primary alcohols to aldehydes. These oxidations generally involve DMSO activation by another species such as dicyclohexylcarbodiimide [Pfitzner-Moffatt oxidation], oxalyl chloride [Swern oxidation] or pyridine sulfur trioxide [Parikh-Doering].
July 22-24 | Controlled Release Society Annual Meeting
Congratulations to our Gaylord Chemical associates for achieving nearly 500,000 work-hours (6-years) since our last OSHA recordable incident.
…synthesis of β,γ – unsaturated ketones which uses arylacetylenes and ketone starting materials.
A recent report by Cheng, Jia, and Kuang (1) of Tongji University is a useful – and pleasantly straightforward- addition to the methods available for alkyne synthesis. The Terminal Alkyne Synthesis of Kuang et Al. (1) The alkyne functionality is crucial to modern methods (Sonogashira coupling, ’Click’ chemistry, methathesis reactions) and terminal alkynes
Alkyl halides are a most fundamental functional group and are useful in many reactions. Typically alkyl chlorides are derived from alkanols, and Dudley Snyder of Pennsylvania State reported an attractive synthesis which uses a ‘DMSO-activated’ TMSCl intermediate (1) An example from the Dudley paper (1) There are some
Li, Han, and coworkers of the Dalian Institute of Chemical Physics have reported an isocoumarin synthesis that proceeds through a nucleopalladative-oxidation olefination pathway (1). Li, Han, and coworkers report the oxidative coupling of olefins and t-butyl 2-alkynylbenzoates to produce isocoumarins (1) The isocoumarin products formed
A recent report (1) from workers at Chonnam National University (Gwangju, Korea) describes a benzimidazole synthesis which: produces good product yields (40-98%, for about 30 examples) and proceeds in one pot from three readily available components: sodium azide, an aldehyde, and 2-haloanilines shows good functional group tolerance(nitro-, ester-, chloro-,
The work of Lee, Song and coworkers (1) provides an versatile route to symmetrical and unsymmetrical diarylalkynes. Their method is complementary to the powerful Sonagashira coupling of aryl halides and alkynes, and offers an alternative to the established ways to make diarylalkynes.