The Quinolones have medicinal properties that make them important agent for the treatment of cystic fibrosis and bacterial infection. Important examples from this class include Ciprofloxacin hydrochloride and Norfloxacin.
The piperidine addition step is effectively performed in hot DMSO. DMSO is an especially useful solvent for nucleophilic substitution reactions using amine nucleophiles. Gaylord Chemical Company L.L.C.’s exclusive Comparative Reaction Solvent program has developed data which suggests that DMSO is the preferred solvent for such transformation, even relative to other dipolar aprotic solvents.
Related Resources
DMSO PharmaSolvent Product Sheet
Synthesis Corner: SnAr reactions with amines