Dinitrophenyl ether herbicides such as acifluorfen (BlazerŽ) and lactofen (CobraŽ) are synthesized via nucleophilic aromatic substitution (SNAr) reaction between phenol and aromatic halide substrates. DMSO offers rate advantages in these reactions.
Leading Reference: Kingsbury, C.A J. Org. Chem. 29 3262-3270 (1964)
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